In October 1989 Regent house began treating patients at 34 Regent St Chippendale. This is the building next door to the current Clinic 36 treatment centre. It was an old dark building with steep stairs to consulting rooms on the first and second floors. The clinic waiting room was small and dingy but it represented a step forward considering the huge unmet demand for methadone treatment services in the city of Sydney. At that time there was only one other private clinic operating and that was garden court in Enmore.

Drs Keith Roberts, Raymond Seidler and the late Peter Bruce practised at the original Regent house until in 1992 the clinic moved to its Waterloo site on 33A Botany Rd, where had it had been a general medical practice run by Dr Selecki. The new clinic was larger, renovated and fully computerised from its first day of operation in 1992. It represented a state-of-the-art private clinic with the first electronic pump utilised by methadone treatment service in Australia.

Since then the clinic has treated many thousands of patients and provided hope to those who would otherwise be in the throes of serious opioid addiction.

Regent house has operated continuously since October 1989 and has successfully reduced harm to a large population of opioid dependent clients.